This year’s theme, Meaning in Medicine: Making a Difference, stems from the many challenges faced and achievements made by the graduate medical education (GME) community while navigating continued uncertainty. As physicians, educators, leaders, and medical professionals, the GME community is in a unique and important position to advocate for high-quality, equitable patient care and its positive impacts on society. The past three years have led to critical scientific advances and examples of the strength of the human spirit, while also spotlighting significant health care disparities and inequities. The ACGME looks forward to gathering the GME community to learn, discover, and challenge each other with a renewed focus on making a difference, together.